Mexico high efficiency plasticizer chemical uses DIBP

Mexico high efficiency plasticizer chemical uses DIBP

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Mexico high efficiency plasticizer chemical uses DIBP

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Mexico high efficiency plasticizer chemical uses DIBP

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Mexico high efficiency plasticizer chemical uses DIBP

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Mexico high efficiency plasticizer chemical uses DIBP

diisobutyl phthalate

Mexico high efficiency plasticizer chemical uses DIBP
  • What is the metabolite of DIBP?
  • The main metabolite of DiBP is mono-isobutyl phthalate (MiBP), which makes up 70% of the excretion products. MiBP can be oxidized to either 2OH-mono-isobutyl phthalate (2OH-MiBP) or 3OH-mono-isobutyl phthalate (3OH-MiBP), which make up 20% and 1% of the excretion products respectively.
  • Is DIBP toxic?
  • DIBP has been found to be relatively non-toxic, but high levels of exposure to the compound may cause irritation to the eyes, skin and respiratory tract. However, in recent years, concerns have been raised about the potential health risks of exposure to phthalates, including DIBP.
  • Can DIBP be oxidized?
  • Oxidation: DIBP can be oxidized in the presence of ozone or other reactive oxygen species. The formation of various oxidation products, including aldehydes, ketones, and carboxylic acids can be expected
  • How is DIBP synthesized?
  • DIBP is synthesized by reaction of phthalic anhydride with isobutanol. Various acids are used as a catalyst, such as sulfuric acid, sulfonated graphene, or iron (III) chloride. Water is a byproduct. Using sulfuric acid, the yield is 61% yield.
  • How does DIBP affect PPAR?
  • DIBP also affected PPAR expression in the liver and testes. Significantly reduced T production. Reduced fetal AGD, T levels, and Insl3. Doses ≥ 250 mg DIBP/ (kg day) resulted in reduced AGD, and retained thoracic areolas/nipples at both early postnatal life, and adult necropsy.
  • How does DIBP affect fetal gynecology?
  • AGD was reduced at GD 19 and GD 20/21 in males and increased in females exposed to DIBP. It also reduced bodyweights of male and female fetuses. Reduced maternal body weight gain from 73 g in controls to 48 and 43 g in the 600 and 900 mg/kg/day dose groups, respectively. Reductions in fetal plasma leptin levels and in fetal insulin levels.