2025 new chemical uses DMP plasticizer in Congo

2025 new chemical uses DMP plasticizer in Congo

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2025 new chemical uses DMP plasticizer in Congo

dimethyl phthalate: uses and toxicity chemical plasticizers

2025 new chemical uses DMP plasticizer in Congo

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2025 new chemical uses DMP plasticizer in Congo

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2025 new chemical uses DMP plasticizer in Congo

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2025 new chemical uses DMP plasticizer in Congo
  • How much monomethyl phthalate (DMP) is toxicity?
  • After an orally administered dose of 0.1mL of DMP, about 77% of monomethyl phthalate and 8% of DMP have been detected in urine collected for 24 hours from male rats. Acute oral toxicity results in an LD50 of 8,2, 5,2, 2,9, 10,1 and 8,6 mg/kg for rats, rabbits, guinea pigs, chicks, and mice respectively.
  • Is dimethyl phthalate carcinogenic?
  • The U.S Environmental Protection Agency has classified Dimethyl phthalate as not classifiable for human carcinogenicity. Its oral LD50 is 4390 to 8200 mg/kg bw/d in rats and the dermal LD50 is 38000 mg/kg bw in rats and more than 4800 mg/kg bw in guinea pigs.
  • Does DMP cause liver damage?
  • Increased liver weight was identified in rats exposed to DMP concentrations of approximately 1,860 mg/kg-day; heightened alkaline phosphatase activity (indicating liver damage) followed prolonged dosage of 500 mg/kg–day; lowered cholesterol and lipid levels were observed after exposure to 107 mg/kg-day.
  • Can DMP be absorbed in rats?
  • Studies have shown that DMP is readily absorbed in the gastrointestinal tract of rats. After an orally administered dose of 0.1mL of DMP, about 77% of monomethyl phthalate and 8% of DMP have been detected in urine collected for 24 hours from male rats.
  • How does DMP affect red blood cells?
  • At high doses (1000 mg/kg), DMP may cause red blood cells (RBCs) to lose their oxygen-carrying function. In both in vitro and in vivo rat studies, DMP-incubated red blood cells released iron. Iron is the site of oxygen binding for hemoglobin, without it, hemoglobin is unable to bind to oxygen and transport it to the rest of the body.