efficient analysis of toxicity and mechanisms of acetyl
- Type:Adsorbent
- Purity:≧99.5%
- Grade:Top grade
- Color:Oily liquid
- Storage:Dry place
- Transport:By sea,courier
- Sample:Availabe
- Certification:CCIC
- Features:Best Price
- Production Capacity:80000tons/year
- Package:200kg/1000kg IBC drum/fleixtank
- Usage:Oil drilling auxiliary agent
in this study, we apply cyber toxicology and molecular docking to elucidate the potential toxicity and underlying mechanisms of the widely used plasticizer additive acetyl tributyl citrate (ATBC).
plasticizer ATBC acetyl tributyl citrate cas no. 77-90-7,goyenche-ATBC acetyl tributyl citrate is an environmentally friendly plasticizer with high thermal stability, cold resistance, light resistance, and water resistance. it is not easy to change color when added to products and can endow products with transparency and low temperature resistance.
what is acetyl tributyl citrate / ATBC? longchang chemical
- Type:Chemical auxiliary agent
- Purity:99.599%
- Grade:Industrial grade
- Color:Transparent
- Storage:Ventilated and dry place
- Transport:By air,courier
- Sample:Free
- Certification:CCIC
- Features:High performance
- Production Capacity:500000ton /year
- Package:In drum
- Usage:Used in lubricants and other industries
what is acetyl tributyl citrate / ATBC? acetyl tributyl citrate is an organic substance with a chemical formula of c20h34o8. it is a colorless, odorless, oily liquid, soluble in most organic solvents, but insoluble in water.
acetyl tributyl citrate chemical plasticizer price,acetyl tributyl citrate is primarily based on natural citric acid obtained from the fermentation of corn. ester derivatives have a long history of use in various applications such as food and beverages, sweeteners, medical, and pharmaceutical. properties. phthalate-free; enhanced flexibility; biodegradability; appliation areas. plasticizers
acetyl tributyl citrate (ATBC) chemical supplier manufacturer
- Type:Plastic plasticizer
- Purity:≧99.5%
- Grade:Industrial grade
- Color:Transparency liquid,no suspended
- Storage:Store at dry, cool place
- Transport:By air,courier
- Sample:Free
- Certification:CCIC, REACH, BV ISO SGS
- Features:high plasticizing efficiency
- Production Capacity:500 metric ton/ per month
- Package:180kg/drum
- Usage:Paper chemicals, plastic auxiliary agents
effective analysis of thyroid toxicity and mechanisms of price,the objective of this study was to elucidate the complex effects of acetyl tributyl citrate (ATBC) on the thyroid gland and to clarify the potential molecular mechanisms by which environmental pollutants influence the disease process.
acetyl tributyl citrate (ATBC) is used as a biodegradable plasticizer for pvc and cellulose derivates, and it is approved for food contact materials and can even be used as a food additive. ATBC is also used as an emollient for personal care/cosmetics products such as aerosol hair sprays and nail polishes.
acetyl tributyl citrate (ATBC) manufacturers and suppliers
- Type:PVC plasticizer
- Purity:98%
- Grade:Top grade
- Color:Oily liquid without visible impurities
- Storage:Stored at a dry, shady, ventilated place
- Transport:By courier, air or sea
- Sample:Availabe
- Certification:CCIC, REACH
- Features:Eco-frindly
- Production Capacity:5000mt
- Package:200kg/drum (IBC, tanker or liquid bag)
- Usage:PVC plasticizer, solvent, rubber, paint, etc
acetyl tributyl citrate (ATBC), an ester derived from the acetylation of tributyl citrate (TBC), is a colorless, odorless oily liquid. as a non-toxic and safe plasticizer, ATBC exhibits excellent heat resistance, cold resistance, light stability, and water resistance.
material safety data sheet ATBC guidechem,ATBC section 1 chemical product and company identification product name: ATBC chemical name: acetyl tributyl citrate synonym name: acetyl tributyl citrate cas no.: 77-90-7 einecs no.: 201-067-0 chemical formula: c20h34o8 customs tariff no: 2918.15 contact information: qingdao abel technology co. ltd. rm. 901, east-towe tianhe international,
pharmacokinetic properties of acetyl tributyl citrate, a
- Type:Insoluble in water
- Purity:≧99.5%
- Grade:Top grade
- Color:Transparency liquid,no suspended
- Storage:Dry place
- Transport:By sea,courier
- Sample:Availabe
- Certification:CCIC
- Features:Best Price
- Production Capacity:50000kg/day
- Package:180kg/drum
- Usage:Coating auxiliary agents, leather
jun 10, 2018 · in the present study, we developed an analytical method for the pharmacokinetic analysis of ATBC using liquid chromatography tandem mass spectrometry (lc ms/ms). based on the developed method, we investigated the pharmacokinetic properties of ATBC in vitro and in vivo. 2. materials and methods. 2.1. chemicals and materials.
material safety data sheet acetyl tributyl citrate,only selected registry of toxic effects of chemical substances (rtecs) data is presented here. see actual entry in rtecs for complete information. no ecological problems are to be expected when the products is handled and used with due care and attention.
- Does ATBC stably interact with target genes?
- To substantiate our analytical findings, we conducted a molecular docking study, which unveiled a pronounced affinity between ATBC and the five core target genes—AR, HDAC1, CREBBP, STAT3, and PARP1.This discovery suggests that ATBC has the capacity to spontaneously and stably interact with these target genes.
- Does ATBC pose a clinical risk?
- Current literature does not clearly indicate that ATBC presents a clinical risk. However, as a plasticizer extensively utilized in daily life, ATBC may still present several potential risks due to prolonged and significant human exposure.
- Do cellular senescence core targets bind to ATBC?
- Notably, all four cellular senescence core target proteins showed strong binding to ATBC with binding energies of < −5 kcal/mol, suggesting that ATBC and each of the core targets can spontaneously bind, and also suggesting that they play an important role in the molecular mechanism of ATBC-induced senescence. 3.8.
- What are core targets of ATBC-induced senescence?
- A comprehensive analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways revealed that core targets of ATBC-induced senescence were predominantly enriched in pathways related to the positive regulation of cell proliferation, telomere shortening, cancer, and cellular senescence.
- What is the no-observed-adverse-effect level (NOAEL) for ATBC vs DEHP?
- The European Food Safety Authority (EFSA) reported a chronic toxicological no-observed-adverse-effect level (NOAEL) of 300 mg-kg-1-bw-1 for ATBC, whereas the NOAEL for DEHP was 4.8 mg-kg-1-bw-1 (Rasmussen et al., 2017). Current literature does not clearly indicate that ATBC presents a clinical risk.
