efficient analysis of toxicity and mechanisms of acetyl
- Type:Plastic plasticizer
- Purity:99.6%
- Grade:Industrial grade
- Color:Colorless
- Storage:Cool dry place
- Transport:By air,courier
- Sample:Free
- Certification:ISO/MSDS/COA
- Features:Good comprehensive performance
- Production Capacity:100, 000 tons per year
- Package:1000kg / IBC Tank
- Usage:Plastic auxiliary agents, rubber auxiliary agents
the aim of this study was to apply a network toxicology strategy to investigate the potential toxicity and the molecular mechanisms underlying the aging-induced toxicity of acetyl tributyl citrate (ATBC). utilizing the chembl, swisstargetprediction, and cellage databases, we identified 32 potential targets associated with ATBC exposure and aging.
pharmacokinetic properties of acetyl tributyl citrate, a,product ion mass spectrum of (a) acetyl tributyl citrate (ATBC) and (b) internal standard (is) (atec, acetyl triethyl citrate). 3. results 3.1. analytical method validation ATBC has three ester bonds in its structure. generally, compounds with esters are susceptible to hydrolysis in plasma, making it difficult to analyze ATBC in plasma samples
tributyl acetyl citrate (ATBC) plasticizer supplier price
- Type:Plasticizer for Paint
- Purity:≧99.5%
- Grade:Top grade
- Color:Light yellow oily liquid
- Storage:Dry place
- Transport:By sea,courier
- Sample:Availabe
- Certification:CCIC
- Features:Best Price
- Production Capacity:2000mts
- Package:200 kgs/iron drum
- Usage:Surfactants, leather auxiliary agents
2. with its good performance , it can be used in production of meat and diary packing , pvc medical product and gum and so on ,ATBC make resin good transparency and flexure resistance in low temperature, meantime atb low volatility and low extraction ,stable while heat-seal and color stable. 3. ATBC can make lubricant better lubricating property
material safety data sheet ATBC guidechem,ATBC section 1 chemical product and company identification product name: ATBC chemical name: acetyl tributyl citrate synonym name: acetyl tributyl citrate cas no.: 77-90-7 einecs no.: 201-067-0 chemical formula: c20h34o8 customs tariff no: 2918.15 contact information: qingdao abel technology co. ltd. rm. 901, east-towe tianhe international,
acetyl tributyl citrate c20h34o8 cid 6505 pubchem
- Type:Chemical raw material
- Purity:99.4%
- Grade:Top grade
- Color:Clear, colorless liquid without visible impurities
- Storage:Store in a cool, dry place
- Transport:By courier, air or sea
- Sample:Availabe
- Certification:ISO/MSDS/COA
- Features:Chemical grade
- Production Capacity:500 metric ton/ per month
- Package:200kg Net/Drum, or 1000kg net/IBC tank
- Usage:Plastic plasticizer, solvent etc.
effect of acetyl tributyl citrate on bone metabolism based on,acetyl tributyl citrate (ATBC, cas no. 77 90 7, purity 98 %) was purchased from high purity plasticizer (st. louis, mo, usa), and dimethyl sulfoxide (dmso) was obtained from solarbio (beijing, china). before use, ATBC was dissolved in dmso to create a stock solution, which was then diluted to the desired working concentration using cell culture medium.
two soil degradation studies observed rapid biomineralization of acetyl tributyl citrate. if released into water, acetyl tributyl citrate is expected to adsorb to suspended solids and sediment based upon the estimated koc. acetyl tributyl citrate has been shown to biodegrade extensively in several other biodegradation studies and simulation tests.
acetyl tributyl citrate supplier chemical distributor redox
- Type:Chemical plasticizer
- Purity:99%min
- Grade:Industrial grade
- Color:Colorless to light-yellow transparent liquid
- Storage:Ventilated and dry place
- Transport:By air or sea
- Sample:Free
- Certification:CCIC, REACH, SGS
- Features:High efficiency
- Production Capacity:100 metric tons per month
- Package:1000kgs in ibc drum
- Usage:PVC plasticizer, solvent, rubber, paint, etc
other names. tributyl o-acetylcitrate acetyl tri-n-butyl citrate (ATBC) 1,2,3-propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester tributyl acetyl citrate
material safety data sheet t3db,acetyl tributyl citrate (ATBC) 1. identification of substance / mixture and of supplier product identifier: high purity chemicals synonyms: tributyl 2-acetylcitrate, tributyl o-acetylcitrate other means of identification: cas no. 77-90-7 einecs no. 201-067-0 recommended use of the chemical and restrictions on use.
plasticizer ATBC acetyl tributyl citrate cas no. 77-90-7
- Type:Insoluble in water
- Purity:99.6%
- Grade:Top grade
- Color:Colourless oily liquid
- Storage:Dry place
- Transport:By sea,courier
- Sample:Availabe
- Certification:REACH
- Features:good toughness
- Production Capacity:500000tons
- Package:200 kgs/iron drum
- Usage:Surfactants, leather auxiliary agents
goyenche-ATBC acetyl tributyl citrate is an environmentally friendly plasticizer with high thermal stability, cold resistance, light resistance, and water resistance. it is not easy to change color when added to products and can endow products with transparency and low temperature resistance.
acetyl tributyl citrate (ATBC) primary plasticizer for pvc,acetyl tributyl citrate (ATBC) primary plasticizer for pvc and pvc copolymers chemical nature chemical name :- 2-acetyl-1,2,3-propane tri carboxylic acid tributyl ester trade name :- ATBC molecular formula :- c20h34o8 molecular weight :- 402.5 h 2 c co 2 c 4 h 9 c 2 h 5 co 2 c co 2 c 4 h 9 h 2 c co 2 c 4 h 9 cas number :- 77-90-7 un.
- Does ATBC stably interact with target genes?
- To substantiate our analytical findings, we conducted a molecular docking study, which unveiled a pronounced affinity between ATBC and the five core target genes—AR, HDAC1, CREBBP, STAT3, and PARP1.This discovery suggests that ATBC has the capacity to spontaneously and stably interact with these target genes.
- Do cellular senescence core targets bind to ATBC?
- Notably, all four cellular senescence core target proteins showed strong binding to ATBC with binding energies of < −5 kcal/mol, suggesting that ATBC and each of the core targets can spontaneously bind, and also suggesting that they play an important role in the molecular mechanism of ATBC-induced senescence. 3.8.
- Does ATBC pose a clinical risk?
- Current literature does not clearly indicate that ATBC presents a clinical risk. However, as a plasticizer extensively utilized in daily life, ATBC may still present several potential risks due to prolonged and significant human exposure.
- What are core targets of ATBC-induced senescence?
- A comprehensive analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways revealed that core targets of ATBC-induced senescence were predominantly enriched in pathways related to the positive regulation of cell proliferation, telomere shortening, cancer, and cellular senescence.
- Does ATBC cause aging?
- The results of functional, pathway, and enrichment analyses for both potential and core targets suggest that, although current studies do not provide direct evidence that ATBC can cause aging, the potential risk of cellular senescence and cancer due to ATBC remains.
- What is the no-observed-adverse-effect level (NOAEL) for ATBC vs DEHP?
- The European Food Safety Authority (EFSA) reported a chronic toxicological no-observed-adverse-effect level (NOAEL) of 300 mg-kg-1-bw-1 for ATBC, whereas the NOAEL for DEHP was 4.8 mg-kg-1-bw-1 (Rasmussen et al., 2017). Current literature does not clearly indicate that ATBC presents a clinical risk.
